Study Design

I. Serum collection for "Pretransplant Serum Study":

II. Serum collection for "Posttransplant Serum Study":

Serum Collection Scheme
Pre-Tx First Post-Tx Week One Month Additional Sera
Day 0 Days 2, 6 Day 30 approx. Days 90, 180, 365, 730, yearly thereafter

Serum samples:

1-2 ml serum without additives (minimum 0.5 ml). Two hours after blood donation, the serum should be separated from cell material by centrifugation and frozen and stored at -20°C.

DNA samples:

EDTA blood, buffy coat and in the case of donor also spleen tissue can be frozen and stored at -20°C
Shipment of frozen samples to Heidelberg, Germany, at dates to be announced (twice a year).



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